Comparative effect of Citrus sinensis and carbimazole on serum T4, T3 and TSH levels
Identifieur interne : 000B58 ( Main/Exploration ); précédent : 000B57; suivant : 000B59Comparative effect of Citrus sinensis and carbimazole on serum T4, T3 and TSH levels
Auteurs : Okon Akpan Uduak [Nigeria] ; Elemi John Ani [Nigeria] ; Emmauel Columba Inyang Etoh [Nigeria] ; Adienbo Ologbagno Macstephen [Nigeria]Source :
- Nigerian Medical Journal : Journal of the Nigeria Medical Association [ 0300-1652 ] ; 2014.
Abstract
There are previous independent reports on the anti-thyroid property of
To compare the effect of
Male wistar albino rats weighing 100-150 g were employed in this research. The rats were randomly assigned to four groups of seven rats per group. Group I served as control and were administered distilled water while groups II-IV were administered with 1500 mg/kg of
The results showed that TSH level was significantly (
These findings suggest that FOJ alters thyroid hormones metabolism to reduce their serum levels with a compensatory elevations of TSH level in a direction similar to CARB.
Url:
DOI: 10.4103/0300-1652.132049
PubMed: 25013255
PubMed Central: 4089052
Affiliations:
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Le document en format XML
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and carbimazole on serum T<sub>4</sub>
, T<sub>3</sub>
and TSH levels</title>
<author><name sortKey="Uduak, Okon Akpan" sort="Uduak, Okon Akpan" uniqKey="Uduak O" first="Okon Akpan" last="Uduak">Okon Akpan Uduak</name>
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<author><name sortKey="Ani, Elemi John" sort="Ani, Elemi John" uniqKey="Ani E" first="Elemi John" last="Ani">Elemi John Ani</name>
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<author><name sortKey="Etoh, Emmauel Columba Inyang" sort="Etoh, Emmauel Columba Inyang" uniqKey="Etoh E" first="Emmauel Columba Inyang" last="Etoh">Emmauel Columba Inyang Etoh</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative effect of <italic>Citrus sinensis</italic>
and carbimazole on serum T<sub>4</sub>
, T<sub>3</sub>
and TSH levels</title>
<author><name sortKey="Uduak, Okon Akpan" sort="Uduak, Okon Akpan" uniqKey="Uduak O" first="Okon Akpan" last="Uduak">Okon Akpan Uduak</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo, Akwa Ibom, Nigeria</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo, Akwa Ibom</wicri:regionArea>
<wicri:noRegion>Akwa Ibom</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ani, Elemi John" sort="Ani, Elemi John" uniqKey="Ani E" first="Elemi John" last="Ani">Elemi John Ani</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Cross River, Nigeria</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Cross River</wicri:regionArea>
<wicri:noRegion>Cross River</wicri:noRegion>
</affiliation>
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<author><name sortKey="Etoh, Emmauel Columba Inyang" sort="Etoh, Emmauel Columba Inyang" uniqKey="Etoh E" first="Emmauel Columba Inyang" last="Etoh">Emmauel Columba Inyang Etoh</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of Obstetrics and Gunaecology, University of Uyo Teaching Hospital, Uyo, Akwa Ibom, Nigeria</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Obstetrics and Gunaecology, University of Uyo Teaching Hospital, Uyo, Akwa Ibom</wicri:regionArea>
<wicri:noRegion>Akwa Ibom</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Macstephen, Adienbo Ologbagno" sort="Macstephen, Adienbo Ologbagno" uniqKey="Macstephen A" first="Adienbo Ologbagno" last="Macstephen">Adienbo Ologbagno Macstephen</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Department of Physiology, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria</nlm:aff>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Physiology, University of Port Harcourt, Port Harcourt, Rivers State</wicri:regionArea>
<wicri:noRegion>Rivers State</wicri:noRegion>
</affiliation>
</author>
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<series><title level="j">Nigerian Medical Journal : Journal of the Nigeria Medical Association</title>
<idno type="ISSN">0300-1652</idno>
<idno type="eISSN">2229-774X</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title>
<p>There are previous independent reports on the anti-thyroid property of <italic>Citrus sinensis</italic>
. This isoflavones and phenolic acid-rich natural agent is widely consumed as dietary supplement, thus the need to investigate its comparative effect with a standard anti-thyroid drug on T<sub>4</sub>
, T<sub>3</sub>
and thyroid stimulating hormone (TSH) levels.</p>
</sec>
<sec id="st2"><title>Objective:</title>
<p>To compare the effect of <italic>Citrus sinensis</italic>
and carbimazole (CARB) on blood levels of thyroid hormones (T<sub>4</sub>
and T<sub>3</sub>
) and TSH.</p>
</sec>
<sec id="st3"><title>Materials and Methods:</title>
<p>Male wistar albino rats weighing 100-150 g were employed in this research. The rats were randomly assigned to four groups of seven rats per group. Group I served as control and were administered distilled water while groups II-IV were administered with 1500 mg/kg of <italic>Citrus sinensis</italic>
(fresh orange juice; FOJ), 0.1 μg/g of levothyroxine (LVT) and 0.01 mg/g of CARB, respectively, per oral once daily for 28 days. The animals were sacrificed under chloroform anaesthesia and blood sample collected by cardiac puncture and processed by standard method to obtain serum. TSH, T<sub>4</sub>
and T<sub>3</sub>
were assayed with the serum using ARIA II automated radioimmunoassay instrument.</p>
</sec>
<sec id="st4"><title>Results:</title>
<p>The results showed that TSH level was significantly (<italic>P</italic>
< 0.05) decreased in LVT treated group compared with the FOJ group. T<sub>4</sub>
was significantly (<italic>P</italic>
< 0.05) decreased in the FOJ and CARB groups compared with the control and LVT groups. LVT significantly increased T<sub>4</sub>
when compared with FOJ group. T<sub>3</sub>
was significantly (<italic>P</italic>
< 0.05) decreased in the CARB group compared with the control.</p>
</sec>
<sec id="st5"><title>Conclusion:</title>
<p>These findings suggest that FOJ alters thyroid hormones metabolism to reduce their serum levels with a compensatory elevations of TSH level in a direction similar to CARB.</p>
</sec>
</div>
</front>
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